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strong cation exchange simulated moving bed (SMB) chromatography, a nitrogen-phosphate-potas-produced in a cost-effective manner. The SMB process operated in a non-traditional way isdivided into production and regeneration sections for exclusion of undesirable ions, and composed of six zones includ-ing two wash-water zones. This paper addreses modeling and simulation studies on the ion-exchange SMB proces, compar-ing simulation results with experimental data obtained both from a pilot plant and an industrial plant. The simulation resultsshow a good agrement with in situ experimental data obtained in the two plants. The model equation validated by the exper-iments will be applicable for optimization problems to obtain optimum operating conditions of the process.