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- Effects of prunella vulgaris L., chrysanthemum indicum L.and pueraria Radixon plasma lipid compositionand histological consideration were investigated in hyperlipidemic rats. Concentration of plasma β-lipoprotein showed atendence to decrease in prunella vulgaris L., chrysanthemum indicum L.and pueraria Radixtreatment groups. Howeverthese values were showed not significantly different from control group. Concentration of plasma FFA in prunellavulgaris L., chrysanthemum indicum L. and pueraria Radixtreatment groups showed a lower values compared to controlgroup and concentration of plasma FFA of prunella vulgaris L. and pueraria Radixtreatment group showed a lowervalues than prunella vulgaris L. and chrysanthemum indicum L. treatment group. Concentration of plasma glucose andtriglyceride showed a tendence to decrease in prunella vulgaris L., chrysanthemum indicum L. and pueraria Radixtreatment groups. However plasma glucose values showed not significantly different from control group. Plasma totalcholesterol concentration showed a low and HDL-cholesterol concentration showed a high in prunella vulgaris L. andpueraria Radixtreatment group. However LDL-cholesterol concentrations were not significantly different in treatmentgroups. Histological consideration of heart, liver and kidney in prunella vulgaris L. and pueraria Radixtreatment groupsshowed a good features in fat accumulation condition than those of other treatment groups. However in the condition ofhigh fat accumulation in tissues, heart, liver and kidney were showed a slight congestion and a bashed cell nucleus.Key words - Prunella vulgaris L., Chrysanthemum indicum L., Pueraria Radixcholesterol, Triglyceride, Glucose, FFA,β-lipoprotein.