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The effects of MgO-P2O5 based sintering additive on the microstructure and material and biological properties of hydroxyapatite (HAp, Ca10(PO4)6(OH)2) ceramic were investigated using XRD, SEM and TEM techniques. The MgO-P2O5 sintering additive improved the material properties and increased the grain size in the sintered HAp bodies. As the content of sintering additive increased over 4wt%, a small amount of the HAp phase was decomposed and transformed to b-TCP. In the 2wt% MgO-P2O5 content HAp sintered body, the maximum values of density and hardness were respectively about 3.10gm/cc and 657HV. However, the maximum fracture toughness in the HAp body containing 8wt% MgO-P2O5 was about 1.02MPa·m1/2 due to the crack deflection effect. Human osteoblast like MG-63 cells and osteoclast like raw 264.7cells were well grown and fully covered all of the HAp sintered bodies. The osteoblast cells were grown with spindle-shaped and the osteoclast cells had a grape-like round shape.