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This article intends to identify a set of factors affecting organizational innovation in central government. Based on Pascale and Athos (1981)’s 7S model, we conducted a survey focusing on consolidated agencies throughout recent history in government innovation. The results indicate that leadership appears to be the major factor affecting innovation and followed by strategy, system, and organizational staff. However, no significant impacts were found in organizational structure, shared values, and skills. These results would contribute to the practice of governmentinnovation by exploring its major determinants.