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Black rice (Oryza sativa L. var. japonica) hasbeen used in folk medicine in Asia. To understand the effectsblack rice, we assesed the expresion levels of about 20,0transcripts in BRP-treated HaCaT keratinocytes using human1A oligo microaray analysis. As a result, the BRP treatmentshowed a diferential expresion ratio of more than 2-fold:745 were activated and 1,011 were represed. One of the mostinteresting findings was a 2-fold increase in hyaluronan synthase2 (HAS2) gene expresion by BRP. Semiquantitative RT-PCRshowed that BRP increased HAS2 mRNA in dose-dependenthyaluronan (HA) production in HaCaT keratinocytes.