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This paper estimate a patent equation to measure the effects of the trade on knowledge diffusion. We find the positive effects of trade and some preferential trade agreements like EU, EFTA and EEA on the international knowledge diffusion. Using a common language shows itself as another factor promoting the international knowledge diffusion. The effect of sharing common border is not robust. We find also that the patenting frequency is increased in proportion to the market size and the absorption capacity of the reporting country and the invention capacity of the country of residence of applicant. The estimation results show that the patenting to the member countries of international or regional patent cooperation agreements is more frequent than that to the other countries. We verify a trend of increasing of patent applications with recent strengthening of intellectual properties.