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While biodegradable, biocompatible poly(L-lactic acid) (PLLA) is a popular material for the manufacture of tissue engineering scaf-folds, its surface properties are not particularly suitable for cell growth. In the present study, poly(L-lactic acid) (PLLA) lms were fab-ricated by a solution casting method and their surfaces were subsequently modied by NaOH hydrolysis. The changes of surfaceproperties were characterized by contact-angle measurement and atomic force microscopy (AFM). Mouse L929 broblasts were usedas model cells to evaluate the cell anity of PLLA before and after surface modication. The results showed that the hydrophilicity20 nm to between 40 and 200 nm. The adhesion and growth of mouse L929 broblasts on modied lms were signicantly improved.Thus, improved hydrophilicity and increased surface roughness at 40200 nm could signicantly enhance cell adhesion and growth onmodied PLLA that could be useful for applications in tissue engineering.