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The purpose of this study is to evaluate the eect of chitosan with absorbable collagen sponge (ACS) carrier on bone formation in therat calvarial defect model. New bone area and defect closure of the chitosan/ACS group were signicantly greater than those of the oth-ers at 8 weeks postsurgery (p < 0.01). Chitosan reconstituted with ACS has signicant potential to induce the regeneration of bone in ratcalvarial critical size defects.