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Introduction: Inflammation plays an important role in the development and progression of atherosclerosis. C-reactive protein (CRP) is associated with future coronary events in healthy population and patients with coronary heart disease. Higher level of physical activity and cardiorespiratory fitness is associated with lower risks of cardiovascular mortality and morbidity, but the underlying mechanisms are not well understood. We therefore hypothesized that better cardiorespiratory fitness results in the lower inflammatory status. And we specifically examined the relationship between peak oxygen uptake and markers of inflammation in such a healthy old men. Methods: We performed graded exercise test on treadmill to determine peak oxygen uptake and blood test(including CRP), measurement of body fat and blood pressure in 102 healthy old men (mean age 62.6± 2.5 years). subject divided into 4 groups such as Q1 (CRP> 0.45mg/dl), Q2 (CRP 0.46-0.85mg/dl), Q3(CRP 0.86-1.84mg/dl), Q4 (CRP<1.84mg/dl). Results: The level of CRP was significant decrease when the fitness level increased (p for trend<0.001). There are positive relationship between CRP and both BMI (r=0.70, p<0.01) and %fat (r=0.72, p<0.01), negative relationship between CRP and VO2peak (r=0.15, p<0.01). Conclusion: This study demonstrates that CRP value were inversely related with cardiorespiratory fitness level. Higher level of cardiorespiratory fitness may have favorable effects on CRP, which may contribute to lower incidence of cardiovascular diseases.