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Purpose: This study was performed to identify the relationship between self-esteem and satisfaction in major of nursing students. Methods: Data were collected from the 10th to the 14th of April in 2006, from 281 nursing students in Jeollabuk-Do area. The collected data were analysed by using the SPSS WIN 11.0. Results: The results of this study were as followings: 1) The mean score for self-esteem was 2.89(±.42), self-esteem was significantly different according to the general characteristics of grade(F=4.718, p= .010), satisfaction of pocket money(F=11.241, p= .000), satisfaction of present life(F=9.875, p=. 000) and hope for the employment field(F=2.583, p= .026). 2) The mean score for satisfaction in major was 3.79(±.49), satisfaction in major was significantly different according to the general characteristics of satisfaction of pocket money(F=5.280, p= .006), motivation of entrance(F=7.384, p= .000), satisfaction of present life(F=27.000, p= .000), hope for the employment field(F=3.019, p= .011) and one of family (t=2.416, p= .017). 3) There was a significant correlation between self-esteem and satisfaction in major(r= .353, p= .000). 4) The most important variables affected satisfaction in major could explain a total 27.9%, were accounted for 22.7% in the satisfaction of present life and 5.2% in the self-esteem by the stepwise multiple regression analysis. Conclusion: As a result, self-esteem was correlated with satisfaction in major in nursing students. Therefore we need to develop various self-esteem program for nursing students.