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Purpose: This study was to identify the important factors for predicting blood donation behavior of medical & nursing college students. Methods: To analyze these issues using logistic regression, we collected data from 230 nursing & medical students of D University in B city by using the self-administered questionnaire from December 12 to December 21, 2004. Knowledge for blood donation was measured by the questionnaire developed by Koo(1982), self efficacy was assessed by General Self Efficacy Scale (Sherer & Maddux, 1982), and altruistic attitude was measured by Altruistic motivation & Responsibility Scale(Jo, 1996). The collected data were analyzed by t-test, Chi –square, and logistic regression by using SPSS/Win 11.0 version. Results: As results of logistic regression analysis, factors which showed significance for predicting blood donation behavior were the perceived health status, family member's experience for the blood donation, religion and gender. Conclusion: It is necessary to improve the perceived health status of college students and to conduct a campaign for blood donation around college students whose family members have had the experience of blood donation in order to increase the rate of blood donation in medical and nursing college students.