초록 close

Linoleic-acid (LA) is covalently conjugated to carboxymethyl-chitosan via a 1-ethyl-3-(3-dimethylaminopropyyl)-carbodiimide-med-iated (EDC-mediated) reaction to generate self-aggregated chitosan nanoparticles by sonication. The average diameter of the particles isloading experiments indicate that the loading capacity and eciency increase with increasing concentration of ADR. ADR is slowlyreleased from chitosan self-aggregates for about 3 days. Furthermore, the eects of drug controlled release become more obvious onincreasing the pH value.