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from tablets coated with starch-based polymer were examined. Maize starch acetates (SA) were prepared by acetyl esterication with adegree of substitution from 1.31 to 2.40, and bovine serum albumin was used as a model drug. Forin-vitrodrug release assays, the starch-based polymer was incubated in simulated gastric uid, simulated intestinal uid and simulated colonic uid, respectively. The resistantstarch content and swelling property of maize starch were increased by acetylation, which retarded its enzymatic degradation. Drugfor a potential drug delivery carrier for colon-targeting biomacromolecule drugs.