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Bioactive coatings containing hydroxyapatite(HA) nano crystals were prepared on PHEMA membrane by a sol dipping method.A cellcoating and the aggregation degree of HA particles inuence the adhesion of the cornea broblasts to the membrane, which dependsdramatically on the weight ratio between the nano-HA and the dispersant. The optimal condition of the coating preparation is with adispersant/HA = 1.25 weight ratio. The PHEMA membrane covered with nano-HA coating is promising for articial cornea use.