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Amphiphilic multiblock Tetronic. PCL copolymer was synthesized by a ring-opening polymerization ofe-caprolactone with Tetro-nic. by using stannous octoate as a catalyst, and Tetronic. . PCL copolymer by using EDC/NHS as coupling agents. The physicochemical properties of these polymers were examined by1H NMR,FT-IR and GPC. The content of bound heparin is measured to be 0.44l g/l g and the heparin activity measured by APTT assay is shownto be 43.6% as compared to free heparin. To estimate the feasibility as a polymeric vehicle of this copolymer for protein delivery, therescence probe technique using pyrene. The diameter of Tetronic. PCL micelle in number-averaged scale was observed to be around25 nm and its size after heparin coupling was increased to 224 nm due to the heparin chain located on the hydrophilic shell of the micelle.Therefore, we suggest that Tetronic. PCLheparin micelle can be a good candidate for the sustained delivery of various proteins withheparin-binding domain in pharmaceutical fields. .