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For tissue regeneration, highly open porous polymer matrices are required for high-density cell seeding, as well as sucient nutrientand oxygen supply to the cells in the 3-D matrices. In this study, three types of scaolds containing three dierent pore sizes (uniform-proliferation with the prepared specimens. Not only DNA quantity measurement of the cells but also the number of cells within thecross-sectional area of the scaold was investigated. In the DNA quantity test, the multi-pore size scaold contained a 1.77 times largeramount than the uniform-pore size scaold for 14 days culture. For the cell-counting assessment, the multi-pore size scaold containedabout 2.24 times more cells than the uniform-pore size scaold in the middle sectioned area for 14 days. To prevent the generation of aobserved in the scaold. Various pore size specimens tended to degrade more and faster than uniform-pore size specimens in PBS solu-tion. Chemical treatment on the surface of the specimen enhances cytocompatibility of the scaold.