초록 close

b-Glucan, a heterogeneous group of glucose polymers, modulates wound healing via macrophages, which are stimulated to releasegrowth factors and cytokines, as well as via glucan receptors on broblasts, which are activated to migrate and synthesize collagen.The placement ofb-glucan/collagen onto an arm of a young child with a scald burn improved healing of a partial-thickness burn wound.! 3), (1! 6)-b-D-glucan on the cytokine release in a macrophage cell line, RAW 264.7, were investigated.The eects ofb-glucan on the proliferation and migration of adult human dermal broblasts (aHDFs) were also examined. When RAW264.7 cells were treated withb-glucan, TNF-a secretion was stimulated in a dose-dependent manner, but IL-6 secretion was not. On theother hand,b-glucan treatment to aHDFs with 1 mg/ml resulted in a signicant (p migration. These results suggest thatb-glucan can stimulate TNF-a release in macrophages and enhance broblast migration, which mayaccelerate wound healing.