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(RBC) were studied. A novel multi-dimensional microscope was employed to perform real time, non-invasivein situmeasurementson the cell shape and size, as well as the membrane bending and shearing elastic moduli of the cell. A phase-analysis micro-electropho-resis laser scattering technique was used to measure the surface charge density. It was shown that the incubation pH markedly inuencesthe surface charge density and the membrane elastic properties of the RBCs and thus leads to a change in their morphology anddeformability.