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release of antibiotics around titanium implants. In this study, titanium oxide was formed by the micro-arc oxidation (MAO) method.Commercially available pure titanium disks with diameter of 10 mm and 2 m in thickness were used as substrates. MAO of the spec-imen was carried out in an aqueous electrolyte by applying a pulsed DC wave to the specimen. The surface characteristics of the MAOimplants, including surface morphology and surface roughness, were analyzed by SEM and surface prolometer, respectively. The pur-phology and alkaline phosphatase activity. The results showed the formation of an oxide layer with micropores and roughness by MAO.No signicant dierence in the proliferation and spreading morphology of machined, blasted and MAO surfaces was observed. However,the ALP activity of osteoblast cells on MAO surface was higher than on machined and blasted surfaces in 4 day and 7 day cultures,respectively. From this study, it was concluded that the MAO-treated titanium exhibited an eect on early osteoblast dierentiation.