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Objective : To evaluate the effect of Samchoolgunbitanggamibang(SGT) on growth of rats. Methods : We divided male Sprague-Dawley rats into 4 groups(S1, S2, S3 and sham group). S1, S2 and S3 groups were administered with SGT water extracts once a day at the dosage 1,000, 500 and 250㎎/㎏/10㎖ for 1 week, 2 weeks, 3 weeks. Sham group was administered with nomal saline for same method. We measured body weight, amount of body weight increasing, length of femur, serum Growth Hormone(GH), serum Insulin-like Growth Factor-Ⅰ(IGF-Ⅰ), serum Thyroid-stimulating Hormone(TSH) and serum testosterone at 1 week, 2 weeks, 3 weeks. Results : The body weight and the changes of body weight increasing of the rats increased significantly in S1 group as compared with sham group after 2 and 3 weeks, in S2 group after 2 weeks. The lengths of the femur increased significantly in S1 group as compared with sham group after 1, 2 and 3 weeks, in S3 group after 1 week. The level of IGF-Ⅰ in the serum increased significantly in S1 group as compared with sham group after 1 and 3 weeks, in S3 group after 3 weeks. The level of TSH in the serum increased significantly in S1 group as compared with sham group after 2 and 3weeks. The level of GH and testosterone in the serum does not change significantly. Conclusion : SGT have an effect of promoting growth of rats and might be effect to treat various kinds of growth delay in children.


Objective : To evaluate the effect of Samchoolgunbitanggamibang(SGT) on growth of rats. Methods : We divided male Sprague-Dawley rats into 4 groups(S1, S2, S3 and sham group). S1, S2 and S3 groups were administered with SGT water extracts once a day at the dosage 1,000, 500 and 250㎎/㎏/10㎖ for 1 week, 2 weeks, 3 weeks. Sham group was administered with nomal saline for same method. We measured body weight, amount of body weight increasing, length of femur, serum Growth Hormone(GH), serum Insulin-like Growth Factor-Ⅰ(IGF-Ⅰ), serum Thyroid-stimulating Hormone(TSH) and serum testosterone at 1 week, 2 weeks, 3 weeks. Results : The body weight and the changes of body weight increasing of the rats increased significantly in S1 group as compared with sham group after 2 and 3 weeks, in S2 group after 2 weeks. The lengths of the femur increased significantly in S1 group as compared with sham group after 1, 2 and 3 weeks, in S3 group after 1 week. The level of IGF-Ⅰ in the serum increased significantly in S1 group as compared with sham group after 1 and 3 weeks, in S3 group after 3 weeks. The level of TSH in the serum increased significantly in S1 group as compared with sham group after 2 and 3weeks. The level of GH and testosterone in the serum does not change significantly. Conclusion : SGT have an effect of promoting growth of rats and might be effect to treat various kinds of growth delay in children.