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Objective : Peel of Citrus unshiu (Rutaceae) has been used in traditional herbal prescriptions. Hesperidin, naringin contents of Citri Unshii Pericarpium have been determined and compared to herbal prescriptions. And then the different extractions from prescriptions are explained with traditional herbal theories. Methods : The remedy extractions of herb and herbal prescriptions were boiled water. A quantitative analysis of hesperidin, naringin using HPLC with reversed-phase C18 column and a UV detecter at 204 nm. Elution was carried out at 1.0 ml/min with 38% methanol. Conclusion and Results : The extract of Citri Unshii Pericarpium for 180 min was the better extracting method that can extracted naringin and hesperidin. And the flavonoid contents in remedies are different from several traditional herbal prescriptions. The reason why the difference can be explained with traditional drug interaction theories.