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Some flavones/flavonols were previously found to inhibit collagenase. To establish a therapeuticpotential for skin inflammation, twenty-three synthetic flavone derivatives were examined for their inhibitorypotential against collagenase from Clostridium histolyticum. From the results, it was found that most of them hav-collagenase inhibitors. Among the synthetic flavones tested, only two synthetic derivatives, 3',4'-dihydroxyfla-vone and 5-hydroxy-4'-methoxyflavone, weakly inhibited bacterial collagenase (13 - 29% inhibition at 50 - 100 M).Keywords . flavonoid, collagenase, matrix metalloproteinase, skin inflamation