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quantification of pholcodine and ephedrine hydrochloride together with either carbinoxamine maleate orterfenadine in antitussive-antihistaminic oral pharmaceutical formulations. Separations were carried out on X-Terra and symetry shield C18 column (250× 4.6 mm, 5m). The used isocratic elution systems were either0.02 M KH2PO4hydroxide, for syrup (method A), or 0.02 octanesulphonic acid sodium salt solution-acetonitrile-acetic acid in theratio of 75 : 25 : 0.5 for suspension (method B). The elution of both mixtures was achieved with a flow rate of 1ml/min. Detection was carried out by UV absorbance at wavelengths of 220 and 250 nm for syrup and suspension,respectively. The quantification of the components in synthetic mixtures and actual syrup and suspension werestandards (IS), respectively. The methods, for both mixtures, were validated and met all the requirements for thequality control analysis recommended by FDA and ICH.Keywords- pholcodine, ephedrine HCl, carbinoxamine maleate, terfenadine, HPLC