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effect(s) of the volatile oil (VO) of Nigella sativa and its two components, α-pinene and ρ-cymeneon body temperature of male and female conscious mice were studied. Further investigations to delineate themechanism(s) of action of the observed efect(s) by using various blockers involved in the central regulation ofbody temperature were made. VO and α-pinene caused significant reductions in rectal body temperature at is and30 minute after treatment. ρVO and α-pinene-induced hypothermia significantly. Nalbuphine inhibited α-pinene-induced hypothermiasignificantly but did not affect VO-induced hypothermia. Droperidol potentiated VO and α-pinene-inducedhypothermia to a non-significant level; whereas atropine potentiated VO-induced hypothermia non-significantly.The study confirms further the role of serotoninergic receptors in the mechanism(s) of the observedpharmacological efects of the VO of Nigella sativa. It also indicated a possible role of opioid receptors in α-KeywordsNigella sativa, α-pinene, ρ-cymene, receptor blockers, serotoninergic receptors