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A 69-year-old man, suffering from diabetes, presented with drowsiness and general weakness is reported. Brain computed tomography revealed low density subdural lesion in the left hemisphere. A single burr hole was trephined and purulent material with liquified hematoma was drained to reveal Klebsiella pneumoniae from the specimen culture. Due to the unexplained postoperative mental deterioration and high fever, the patient underwent abdominal sonography to reveal liver abscess and the same pathogen was also cultured from the liver abscess. This case was very rare in that Klebsiella pneumoniae implanted into the vascularized capsule of the chronic subdural hematoma by hematogenous bacteremia. When chronic subdural hematoma is present in an immunocompromised or in old age patient, the infected subdural hematoma might be considered as one of the differential diagnosis. Key words:Subdural empyema;Chronic subdural hematoma;Infection;Klebsiella pneumoniae.