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Pterocarpus santalinus Linn on acute hepatotoxicity induced in Wistar albino rats by a single dose ofGalactosamine (400 mg/kg). Suspensions of methanolic extract of heartwood of P. santalinus (200 and 400 mg/kg)in 0.3% Carboxy Methyl Cellulose (CMC) were administered p.o. to experimental animals and hepatoprotectiveactivity was monitored by estimating aspartate amino transferase (ASAT, GOT), alanine amino transferase(ALAT, GPT), alkaline phosphatase (ALP), total bilirubin (TB), lactate dehydrogenase (LDH), total cholesterolelevation of serum transaminases and alterations of biochemical parameters induced by hepatotoxin, andalleviated the degree of liver damage. The results were supported by histopathological studies of liver samplesshowing regeneration of hepatocytes in treated animals. Silymarin (25 mg/kg), a known hepatoprotective drug wasused for comparison. Based on the results obtained, it can be concluded that P. santalinus exerts hepatoprotectiveactivity and may serve as a useful adjuvant in several clinical conditions associated with liver damage.Keywords Pterocarpus santalinus