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The authors report two cases of intractable cancer pain, which was managed by bilateral cingulotomy. The technique involved stereotaxis using magnetic resonance guidance and local anesthesia, with the introduction of a mechanical and chemical lesion(absolute alcohol). Postoperative pain relief was excellent that lasted relatively prolonged period of time until disease has far advanced. There were no complications related to procedure. Bilateral stereotactic cingulotomy is considered safe, feasible and most of all, effective in the severe, disabling pain from metastatic lesion. Also, a invasive surgery with general anesthesia can be avoided. Key words:Cancer pain;Bilateral cingulotomy;Mechanical and chemical lesion.