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Objective:Vascular endothelial growth factor(VEGF)-C is involved in lymphangiogenesis and spreading of cancer cells via lymphatic vessels. The aim of the present study is to investigate the relationship between the absence of cerebral lymphatic vessels and low metastatic rate of brain tumors. Methods:Immunohistochemical stains were performed for VEGF-C and VEGF in surgically resected specimens from 57 patients with primary(38 cases, low grade:10 cases, high grade:28 cases) and metastatic(19 cases) brain tumor. Results:The expression of VEGF-C was higher in metastatic carcinoma(68%) than in high-grade primary tumor(29%). There was no difference for VEGF expression between high grade brain tumor (71%) and metastatic carcinoma(58%). Conclusion:Low VEGF-C expression of primary brain tumors may play a role in low metastatic rate of brain tumors. Key words:Primary brain tumor;Metastatic brain tumor;VEGF-C·VEGF.