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Objective:The authors present an investigation of the effect of transglutaminase(TG) on the recovery of somatosensory evoked potentials in the rat model of spinal cord injury. Methods : Female Sprague-Dawley rats(280-310g) were used for this study. Rats were divided into two groups : TG treated and control. The lesion was made by transecting the right dorsal column of the thoracic spinal cord without damage to the vasculature using specially devised micro-glass pipette after laminectomy. For TG treated group, normal saline with TG were injected into the lesion site using micro-pipette through the opening of the dura. Saltatory repetitive somatosensory evoked potentials(SSEPs) recording were carried out on post-injury 6th and 12th week. Results : The amplitudes of N19 were 1.28±1.60㎶ on 6th week, 3.45±3.63㎶ on 12th week in control group(n=10) and 1.46±1.75㎶ on 6th week and 5.01±2.65㎶ on 12th week in TG-treated group(n=11). Statis-tically significant recovery of SSEPs were seen in TG-treated group(p=0.003, Wilcoxon Signed Ranks Test). In TG-treated group, vacuolated degeneration around the lesion site was rarely observed on histological evaluation. Conclusion : This study demonstrates the possibility of long-term survival and saltatory recording of SSEPs in small animals like rats, after selective spinal cord injury. In addition, this study shows that TG is a factor facilitating the recovery of injured axon of central nervous system. Key words:Rat;Somatosensory evoked potentials;Spinal cord injury;Transglutaminase.