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또는 회색을 띄는 섬유신경교성(fibrogliotic nature)을 보였으며 정상 뇌조직이 보일 때까지 전적출을 시행하였다. 뇌농양 수술 후 3일째 농양액의 균도말과 배양검사상 MS-SA가 발견되었으며 6일째 병리조직검사상 농양벽에서 아스페르길루스 균사가 발견되었다(Fig. 4). JH Hur, et al. J Korean Neurosurg Soc/Volume 33/January, 2003 83반코마이신(vancomycin) 4주, 시프러스(ciproflox acin) 2주 및 이트라코나졸(itra-conazole) 400mg을 2주간 경구투여한 후 한달뒤 시행한 뇌전산화단층촬영에서 지름 2~ 3mm의 조영증강되는 병변만 남긴채로 호전되어 퇴원하였다. 퇴원후 약 2개월간 이트라코나졸 경구 투여를 지속하였다.


A staphylococcal brain abscess admixed with aspergillosis occurred after operation for the olfactory groove meningioma at remote site. We report the rare case and consider the clinical pathogenesis. Bifrontal craniotomy for the olfactory groove meningioma was done in a 61-year-old female. She was bedridden for one month after craniotomy. During that period, panhypopituitarism occurred and was corrected with hormonal replacement. Sore in the occipital scalp which had occurred during the bedridden state was cared by dressing. After 60 days of treatment, he was discharged with ambulatory status. During postoperative period, we found left parieto-occipital brain abscess in the brain computed tomography(CT) at 3 months. And then craniotomy and abscess resection was performed. Vancomycin and itraconazole antibiotic therapy was instituted after the identification of staphylococcus and aspergillus in the cystic fluid, and aspergillus hyphae in the solid wall portion of the abscess. After the confirmation of resolution of brain abscess on the postoperative 3 weeks' brain CT, the patient was discharged with oral itraconazole medication. Key words:Aspergillus;Staphylococcus;Postoperative period;Brain abscess.