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Venlafaxine is often considered to be safer than established antidepressants except the risk of hypertension. In terms of vaginal bleeding associated with venlafaxine, only one case has been reported. We describe a vaginal bleeding occurred in a 38-year-old depressed patient who has been receiving additional venlafaxine during fluoxetine medication. Discontinuation of venlafaxine supported the assumption that the vaginal bleeding was an adverse drug reaction of venlafaxine. Physicians should be alerted to the possibility of bleeding tendency in patients who have taken venlafaxine.