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목 적 : 연취급 근로자들에서 연노출이 간기능에 미치는 영향을 알아보기 위하여 시도되었다. 방 법 : 모 1차 제련업체에서 연을 취급하는 남자 근로자들 중 B형 간염 항원 보균자 및 간장질환 경험이 있는 근로자를 제외한 274명을 대상으로 하였고, 대조군은 B형 간염 항원 및 간장질환 경험이 없으면서 과거 직업력상 연을 취급하는 직장에 근무한 적이 없는 제조업체 생산직 근로자 113명을 대상으로 하였다. 연노출의 지표로서는 혈중 연량, 혈중 zinc protoporphyrin, 요중 δ-aminolevulinc acid 등을 측정하였고, 간기능의 지표로서 aspartate aminotransferase (SGOT), alanine aminotransferase (SGPT), γ-glutamyltransferase (γ-GTP)를 측정하였며, 또한 간기능에 영향을 줄 수 있는 혼란변수로서 연령, 흡연량(pack-year), 음주량(주간 평균 마신 술을 2홉들이 소주병 수로 환산), 체질량지수(BMI) 및 연 노출기간을 조사하였다. 간기능 지표(SGOT, SGPT, γ-GTP)의 결과를 각각의 기준치(reference value)에 의거 정상과 비정상으로 판정한 후, 각 비정상 결과에 대한 각 변수들의 영향을 로지스틱 회귀분석하였고, 또한 간기능 지표(SGOT, SGPT, γ-GTP)에 연노출 지표가 미치는 영향을 확인하기 위하여 혈중 연 농도, 혈중 ZPP, 요중 δ-ALA를 각각 독립변수로 하여 다중회귀분석을 실시하였으며, 혼란변수로서 연령, 체질량지수, 흡연량 및 음주량, 연 노출기간 등이 포함되었다. 최종모델은 동일한 혼란변수를 포함하도록 하였다. 결 과 : 비정상 SGOT(>35 IU/L)에 대한 로지스틱 회귀분석 결과, 혈중연 농도의 비차비는 1.04 (95 % CI, 1.008-1.066)였으며, 음주량 (비차비 1.28 : 95 % CI, 1.054-1.549)과 체질량지수 (비차비 1.24 : 95 % CI, 1.075-1.421) 역시 유의한 변수로 나타났다. SGOT를 종속변수로 하고 연령, 체질량지수(BMI), 연노출 근무기간 그리고 흡연량 및 음주량을 통제한 중회귀분석에서 혈중 연농도는 SGOT를 유의하게 증가시키는 것으로 나타났다(p<0.05). 결 론 : 연은 연노출 남자 근로자의 간기능 지표 중 SGOT에 유의한 영향을 미칠 수 있는 것으로 나타났다.


Objectives - To evaluate the effects of lead on the liver function indices in male lead workers. Methods - The study comprised of 274 lead workers and 113 non-lead workers who were confirmed not to have HBsAg (Hepatitis B surface Antigen). Blood lead (PbB), blood zinc protoporphyrin (ZPP) and urinary δ-aminolevulinic acid (ALAU) were selected as parameters for monitoring exposure to lead while aspartate aminotransferase (SGOT), alanine aminotransferase (SGPT) and γ-glutamyltransferase (γ-GTP) were chosen as parameters for monitoring liver function. Demographic information, such as age, smoking and drinking histories were collected. The duration of work for the lead workers, and their BMI(body mass index), were also obtained. Results - After adjusting for possible confounders {age, BMI, work duration, smoking (pack-year) and drinking (bottles of Soju consumed per week)}, blood lead was observed to be a significant variable from the logistic regression analysis of the abnormalities of SGOT(>35 IU/L), with an odds ratio of 1.04 (95 % CI, 1.008-1.066). The amount of alcohol drunk (odds ratio 1.28 : 95 % CI, 1.054-1.549) and BMI (odds ratio 1.24 : 95 % CI, 1.075-1.421) were also significant variables. From the multiple linear regression analyses, blood lead was significantly, and positively, associated with SGOT (p<0.05). Conclusions - These findings suggest that exposure to lead may have an effect on SGOT in male lead workers.


Objectives - To evaluate the effects of lead on the liver function indices in male lead workers. Methods - The study comprised of 274 lead workers and 113 non-lead workers who were confirmed not to have HBsAg (Hepatitis B surface Antigen). Blood lead (PbB), blood zinc protoporphyrin (ZPP) and urinary δ-aminolevulinic acid (ALAU) were selected as parameters for monitoring exposure to lead while aspartate aminotransferase (SGOT), alanine aminotransferase (SGPT) and γ-glutamyltransferase (γ-GTP) were chosen as parameters for monitoring liver function. Demographic information, such as age, smoking and drinking histories were collected. The duration of work for the lead workers, and their BMI(body mass index), were also obtained. Results - After adjusting for possible confounders {age, BMI, work duration, smoking (pack-year) and drinking (bottles of Soju consumed per week)}, blood lead was observed to be a significant variable from the logistic regression analysis of the abnormalities of SGOT(>35 IU/L), with an odds ratio of 1.04 (95 % CI, 1.008-1.066). The amount of alcohol drunk (odds ratio 1.28 : 95 % CI, 1.054-1.549) and BMI (odds ratio 1.24 : 95 % CI, 1.075-1.421) were also significant variables. From the multiple linear regression analyses, blood lead was significantly, and positively, associated with SGOT (p<0.05). Conclusions - These findings suggest that exposure to lead may have an effect on SGOT in male lead workers.