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Aneurysm surgery using titanium clips has been popularized, although confronted by some minor drawbacks and the paucity of long-term clinical results about the safety of these implants. The authors recently experienced an unusual case of postoperative titanium clip slippage in surgery for anterior communicating artery aneurysm in a 38-year-old man. Aneurysm reoperation with implanting of two cobalt alloy clips was followed. We reviewed the mechanical characteristics of the titanium clips and technical considerations in clipping, and then tried to search for solutions to prevent this kind of complication. Key words:Intracranial aneurysm;Titanium clips;Slippage;Reoperation.