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We report a case of de novo development of cavernous malformation after cranial irradiation. The patient was a 19-year-old male who had been operated on 10 years ago for cerebellar pilocytic astrocytoma. After subtotal tumor removal, he had received cranial irradiation for the residual tumor. He was readmitted for extraocular muscle palsy, dysarthria and facial weakness about 10 years after operation and irradiation. Magnetic resonance imaging of the brain showed an abnormal mixed signal lesion in the lower pons and pontomedullary junction. The patient underwent surgical removal of the hematoma in the pons and the cavernous malformation was identified. Key words:Cavernous malformation;Radiation therapy.