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Brunner's gland 과형성은 십이지장에 정상적으로 존재하는 Brunner's gland의 양성 증식을 의미하며 십이지장 양성 종양의 약 10%를 차지한다. 임상 증상은 비특이적이고 다양하며 상복부 불편감, 위장관 출혈, 장폐쇄 등이 나타날 수 있다. 저자 등은 빈혈과 복부 전산화 단층 촬영에서 관찰되는 십이지장 내 종괴를 주소로 내원하여 위내시경에서 십이지장에 Yamada 4형의 거대 용종으로 진단하고 수술한 Brunner's gland 과형성 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.


So called Brunner's gland hyperplasia is characterized by a nodular proliferation of histologically normal Brunner's gland, accompanied by ducts and scattered stromal element. The clinical presentation vary from vague epigastric disomfort to obstruction and gastrointestinal bleeding. We experienced a case of huge Brunner's gland hyperplasia presented as a huge duodenal polyp. A 28-year-old woman was refered to our hospital because of suspicious ampulla of Vater cancer or duodenal cancer in abdominal CT scan. The patient complained of dizziness and intermittent melena. The side view duodenoscopic examination revealed a huge pedunculated mass originated from the posterior wall of the duodenal bulb. The head of the polyp was placed on the ampulla of Vater with several erosions suggesting recent bleeding. Resection of duodenal polyp was performed by laparoscopic duodenotomy and Brunner's gland hyperplasia was revealed on pathologic examination. (Korean J Gastrointest Endosc 2002;24:35-38)