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Objective:The purpose of this study is to analyse the surgical outcome of prolactinoma and to evaluate the treatment modality. Methods:Author has reviewed retrospectively the results of transsphenoidal microsurgical management in 26 patients with prolactin-secreting pituitary adenomas between 1995 and 2000. The patients were divided into three groups based on their preoperative serum prolactin levels:below 200ng/ml(Group A):over 200 to 500ng/ml(Group B):over 500(Group C). Results:During the same period, a total of 120 patients with pituitary adenoma were treated, and prolactinoma was the 21.6%. The mean age was 32.3±9.1 years and sex ratio(male-to-female ratio) was 1:5.5. The common clinical manifestations were amenorrhea, galactorrhea, headache, visual field defect and loss of visual acuity. Mean preoperative serum prolactin level was 1250.3ng/ml. The percentage of successful treatment(control rate) was 92.8% in Group A, 75% in Group B, and 0% in Group C. Conclusion:The surgical control rates seem to justify surgery for these patients. For the most patients with serum prolactin levels over 500ng/ml, adjuvant treatment with bromocriptine after the surgery is recommended. Key words:Prolactinoma;Transsphenoidal approach.