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Objectives:To clarify the effects of Actinidia polygama and CsA on OVA-induced asthma model, we examined the influence of Actinidia polygama fructus extract (APF) and CsA on the number of regulatory T cells, NKT cells and γδ T cells in murine model of asthma. Methods:All mice were immunized on two different days (21 days and 7 days before inhalational exposure) by i.p. injections of OVA in PBS. Seven days after the second sensitization, mice were exposed to aerosolized ovalbumin for 30 min/day on 3 days/week for 12 weeks and APF (400, 40 mg/kg) were orally administered 3 times a week for 8 weeks. Results:The suppressive effects of APF on asthma model were demonstrated by the increase the number of regulatory T cells, γδ T cells and by reducing the number of NK T cells. Conclusion:These results indicate that APF has a deep inhibitory effect on airway inflammation and hyperresponsiveness in murine model of asthma by increase the number of regulatory T cells, and γδ T cells and by reducing the number of NK T cells.


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Actinidiae polygamae fructus (APF), asthma, regulatory T cell, NKT cell, γδ T cell