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Objectives : This study was carried out to investigate the effects of Gami-Shengmayuipungtang on acnes Methods : The effects of Gami-Shengmayuipungtang(SYTSRG) on acnes were measured by the 5α-reductase inhibition, the sterilizing power for propionibactrium acnes, the cytotoxicity of human monocyte, the inhibition for prostaglandins(PGE2), interleukins(IL-1β) and TNF-α in inflammation, and the size of Hamster ear sebaceous gland concerned with Acnes. Results : On the 5α-reductase inhibition of SYTSRG in vitro, An undiluted solution of SYTSRG was 80% inhibition on 5α-reductase and 1/10 diluted solution of SYTSRG was 40% inhibition on 5α-reductase. On the sterilizing power for Propionibactrium acnes concerned in Acnes, an undiluted solution and 1/10 diluted solution of SYTSRG formed 12㎜ clear zone diameters. SYTSRG was not showed the cytotoxicity of human monocyte. 0.01% and 0.04% and 0.08% of SYTSRG inhibited the production of prostaglandins(PGE2) in the human monocyte stimulated with P. acnes LPS. 0.08% and downward of SYTSRG inhibited the production of interleukins(IL-1β) in the human monocyte stimulated with P. acnes LPS. 0.04%, 0.08% and 0.12% of SYTSRG inhibited the production of TNF-α in the human monocyte stimulated with P. acnes LPS. As the antiandrogenic compound, SYTSRG was used in hamster ears with topical application. SYTSRG was diminished on the size of hamster ears sebaceous gland in male, but was not diminished in female. Conclusion : The present data suggest that SYTSRG may effect the primary stage of inflamation on acnes.