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By increasing energy resource cost, the annual energy consumption for a HVAC has been an important factor as well as an initial cost of mechanic system to select a primary plant system. Hence, Life Cycle Cost(LCC) analysis is inevitable need to evaluate the efficiency of plant system. In this study, an economical efficiency of various plant system was validated to present the optimized plant solution for the new hospital for children. An annual HVAC energy consumption is calculated by energy simulation program(DOE 2.1E) and an economic efficiency of each plant system evaluated by LCC analysis method. The essential conclusions of this study are as follows; 1) Because of many specific rooms which need 24hour HAVC, energy consumption per area of the design building is higher than other buildings, 2) A totally hot and chiller water generator(HCWG) system (ALT-1) is the most profitable system in the point of initial cost, However 3) Considering a annual gross energy bill, which is fluctuated by energy source type and a initial cost of system, a composit system(ALT-2), a coupled system by an ice storage system and a HCWG system, is more effective than other systems during system life cycle, 4) A totally absorption system(ALT-3) has no merits of installing the plant system in the point of initial and running cost. Consequently, it is revealed that a composit system(ALT-2) is the most economical plant system for the new constructed building.