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Background and Objectives:Angiogenesis is a necessary process for solid tumor to grow in human body, and thought to play an important role in metastasis. In some solid tumor such as the breast cancer and prostatic cancer, the angiogenesis is thought to be one of the most significant prognostic factors that predict the patient survival rate and metastasis. The purpose of this study is to define the significance of angiogenesis in the head and neck squamous cell carcinoma (HNSCC). Subjects and Method:We measured the microvascular density (MVD)HNSCC. The maximal and average MVD was compared with the clinical parameters such as stage, cervical lymph node metastasis, recurrence, and survival rate, obtained through the retrospective review of the medical records. Results:1) The maximal and average MVD correlated with overall stage, T stage and N stage statistically. The MVD were increased accor-ding to the increasement of the T and N stage. 2) The maximal and average MVD showed a significant relationship with 3 year survival rate. 3)Conclusion:The maximal and average MVD may be a significant prognostic factors which can predict the survival rate of the patients with HNSCC. (Korean J Otolaryngol 2002;45:601-7)