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Background and Objectives:Salicylate is one of the most comonly prescribed drugs although it has been recognized including an impairment of the cochlear blod circulation. But the exact mechanism of salicylate ototoxicity is not known cl-early. The purpose of this present study was to determine if the decreased blood flow after salicylate injection could be the possible cause of hearing loss. Material and Methods:We used the ventral approach to expose cochlea in 5 guinea pigs showing normal Preyer reflex. We simultaneously measured cochlear blood flow (CBF) by laser doppler and distortion pro-(DPOAE) after a high dose of salicylate injection (300 mg/kg). Results:After salicylate injection, the cochlear blood flow were decreased by 29.1% in a 3 hour period and the thresholds of DPOAE were elevated by 5 to 25 dB for 3 kHz, 4 kHz, 6 kHz, 8 kHz. Conclusion:Sodium salicylate caused a decrease in cochlear blood flow and an incr-that the ototoxic mechanism of sodium salicylate could be explained by a certain damage of out hair cell due to decrease in cochlear blood flow. (Korean J Otolaryngol 2002;45:544-9)


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