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The objects were twenty of more than 35 years old fat women who had more than 30% body fat, and their UCP-1 (the uncoupling protein) gene and genetic polymorphism of inspected. Depending upon the existence of mutation, nine women did complex exercise 5 times a week and 60 minutes a day for 12 weeks, in other words, 60∼70% level of the aerobic exercise and 60% level of the weight training, to examine leptin and Insulin, blood lipid and changes of body construction. The findings were as follows: 1. The Changes of Leptin and Insulin After the 12-weeks exercise, the leptin decreased to have no significant difference (p<.05), and the insulin increased to have no significant difference(p<.01) 2. The Changes of Blood Lipid After the 12-weeks exercise, the TC decreased to have no significant difference(p>.05), and the TG increased to have no significant difference (p>.05), and the LDL-C decreased to have no significant difference (p>.05), and the HDL-C increased to have significant difference(p<.05). 3. The Changes of Body Composition After the 12-weeks exercise, the weight decreased to have no significant difference (p<.01), and both the % body fat and the BMI decreased to have significant difference(p<.01).