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This study attempts to investigate whether the Trp64Arg mutation of the beta3- adrenergic receptor( 3-AR) gene affects abdominal fat mobilization and endocrinic function in middle-aged obese women following 12 weeks' aerobic training. Healthy eighteen participants were subdivided into `non- mutation group' and `mutation group'. The participants performed the exercise program at 50%HRreserve for 40min a day, 5days each week for 12weeks. Polymorphism of the 3-AR genes were analyzed with `restriction-fragment- length- polymorphism (RELP)' method. In both groups, the level of serum total cholesterol, HDL-C and HOMA score indicating the level of insulin resistance increased significantly after exercise program, in Trp/Trp group, the amount of increase was greater than the mutation groups. In both groups, the level of abdominal subcutaneous fat volume was decreased, but only non-mutation group showed the significant decrease of abdominal visceral fat volume. In mid thigh, there are no significant difference after exercise training. In conclusion, mutation of the 3-AR genes was found to be associated with the exercise-mediated improvement in abdominal subcutaneous/visceral fat and body composition in healthy Korean women.