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Eighteen methanol extracts of herb-medicine used for malarial and antipyretic therapies in Korea were assessed for their antimalarial activities. Eighteen extracts showed evident antimalarial activity with EC50 values ranged from 2.8 to 110㎎/㎖. Evodia fructus showed the antimalarial activity of EC50 = 4.1 ㎎/㎖ and higher selective toxicity(>8) with no cytotocixity for mammalian cells. This indicated that Evodia fructus is potent for a new effective and safe antimalarial agent. The methanol extract of Physalli radix had also strongest antiplasmodial activity with EC50 value of 2.8㎍/㎖