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Oncocytic glomus tumor is a newly recognized, rare variant of glomus tumor. In this study, we describe a case of oncocytic glomus tumor occurring in the nail bed of the finger. A 25-year-old woman presented with a tiny and painful mass on her hand, and she had had this lesion for six years. Upon microscopic examination, there were oval to polygonal tumor cells characterized by plump eosinophilic granular cytoplasm, which were arranged in sheets around the thin vessels. Immunohistochemically, the tumor cells were strongly reactive for smooth muscle actin, vimentin, and negative for S-100 protein, alpha-fetoprotein, HMB-45, desmin, CD34, and pancytokeratin. The diagnosis was a glomus tumor of the oncocytic variant.


Oncocytic glomus tumor is a newly recognized, rare variant of glomus tumor. In this study, we describe a case of oncocytic glomus tumor occurring in the nail bed of the finger. A 25-year-old woman presented with a tiny and painful mass on her hand, and she had had this lesion for six years. Upon microscopic examination, there were oval to polygonal tumor cells characterized by plump eosinophilic granular cytoplasm, which were arranged in sheets around the thin vessels. Immunohistochemically, the tumor cells were strongly reactive for smooth muscle actin, vimentin, and negative for S-100 protein, alpha-fetoprotein, HMB-45, desmin, CD34, and pancytokeratin. The diagnosis was a glomus tumor of the oncocytic variant.