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Objective : The purpose of this study is to examine the tendency of experimental studies on the physiological effects of acupuncture at ST36(Zusanli). Methods : We investigated 69 theses (10 Korean and 59 international) which were searched by the keyword 'Zusanli' through PubMed website, and that were experimented with manual acupuncture or electroacupuncture on healthy human subjects or normal animals. Results : The 69 theses were classified into four groups based on the main topic which is related with the influence of acupuncture stimulation at ST36(Zusanli), such as digestive system, nervous system, immune system, and cardiovascular system. The main results found in this study are : 1. Acupuncture at ST36(Zusanli) increases gastric mobility. And such effect is related with vagal nerve and opioid pathway. 2. Acupuncture at ST36(Zusanli) is valuably related with cerebral cortex. And it influences on the cerebrum activities. 3. Acupuncture at ST36(Zusanli) has noticeable analgesic effect, which is related with Opioid mechanism, Gate control and SP. 4. Acupuncture at ST36(Zusanli) increases immunity. Conclusion : Acupuncture at ST36(Zusanli) has many effects on digestive system, nervous system, immune system, and cardiovascular system.