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In our country, Cardiovascular disease(CVD) and Coronary heart diseases(CHD) is the leading cause of death. It is well known that CHD is multifactorial, involving both with environmental factors such as diet, level of exercise and cigarette smoking, and inherited factors. According to the statistic data in 2003, the cause of death with the highest mortality was including hypertension, ischemic heart disease and atherosclerosis, which accounted for 24.7% of total mortality. In spite of, there has been few study reports on the change of biochemical marker and mechanism concerned. The development of biochemical marker is required for an early diagnosis and treatment of cardiovascular diseases that is related with dietary habit of Korean people enjoying mixture of traditional dietary style and westernized food-style. Therefore, the most efficient cost-saving biochemical marker was established in this study, through analysis of biochemical marker related with dietary habit which is susceptibly being changed in association to cardiovascular diseases from the pre-disease phase, and through reanalysis and assessment of early diagnosis of and preventive effect of diagnosis of cardiovascular diseases by demographical character including sex, age, and socioeconomic level with use of biochemical marker that is identified and selected among the parameters in consideration of the effectiveness and appropriateness of early diagnosis of diseases. The appropriateness of biochemical markers was reviewed by professionals (medical, pharmaceutical area and food/nutrition area) and CRP(C-Reactive Protein) was identified to be possible in Korea. It is thought that this biochemical marker may be used as the basic data for early diagnosis and prevention of cardiovascular diseases(CVD) which may be used for Korean people.