초록 close

Purpose : Nowadays, many studies of growth retardation treatment by the oriental medical therapy are progressed. This study was performed to evaluate the effect of Hwalhyulsungjang-san(Huoxuechengzhang-san) and KC101 on physical development in growth.Methods : 60 young(3 weeks old) male rats, which mean weight was 46.8±0.7g, were divided into 5 gruop : group A, B, C, D were fed on experimental diet each containing Hwalhyulsungjang-san 2.5%, Hwalhyulsungjang-san 7.5%, KC101 5.0%, KC101 10.0%, and the other group were fed on AIN-diet not containing Hwalhyulsungjang-san nor KC101 as control group. study of each group was used 2 rats and was repeated in 6 times. body weight, daily weight gain, dietary intake, body length, femur length, backbone length and serum concentration of IGF-I and hemoglobin were measured.Result :1. body weight and daily weight gain of group D(KC101 10%) were highest, dietary intake of group D was also increased to 13% compared to control group.2. body length of group D was increased to 1.69cm, which was 3.2% compared to control group. backbone length of group D was also increased to 4% compared to control group.3. serum concentration of IGF-I of group D increased to 17% compared to control group.4. serum concentration of hemoglobin of group B(Hwalhyulsungjang-san 7.5%) was increased to 8% compared to control group.Conclusion : this study showed that Hwalhyulsungjang-san and KC101 composed of oriental medicinal stuffs have effect on physical development in growing rats. there were not any statistical meaning compared to control group. but this study suggests that oriental medicinal stuffs intake from young may lead to increase physical development in growth.