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The purpose of this study is to investigate antioxidant, whitening and anti-inflammatory effects of Centella asiatica extracts using supercritical extraction. In addition, Franz diffusion cell experiment was conducted using polymer micelle and cell permeation peptide for transdermal delivery. The DPPH radical scavenging test showed the highest DPPH radiated scavenging of C. asiatica water extract (CWE) and the SOD-like activity experiment represented that C. asiatica ethanol extract (CEE) was the highest SOD-like activity. However, C. asiatica supercritical extract (CSE) also showed good results in DPPH radical scavenging and SOD-like activity. In the inhibition test of melanin induced by α-MSH in B16 cells, CWE & CEE showed melanin inhibiting at high concentrations, but less than 20% at concentrations below 200 μg/mL. CSE represented melanin inhibiting at less than 50 μg/mL and almost 50% inhibition at the concentration. The inhibitory results of NO (nitric oxide) generation induced by LPS showed 88% by CWE at a concentration of 800 μg/mL compared to control treated only by LPS, 13% by CEE at a concentration of 200 μg/mL, 71% by CSE at a concentration of 100 μg/mL, and concentration-dependent increases in inhibits were found in CWE & CSE. For the skin permeability, in vitro experiment was conducted using polymer micelle and cell permeation peptide (R6) using the indicator material for CSE. The experiment showed that polymer micelle and cell permeation peptide effectively helped permeate the percutaneous tissue of CSE.