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루푸스에서 근위부 근침범은 비교적 흔하나, 원발성 염증성근염이 동반된 경우는 흔치 않다. 저자들은 루푸 스와 전형적인 피부근염의 발진을 보인 피부근염이 동 반된 27세 여자 환자와, 원발성 염증성근염의 특이 항체 인 항-Jo-1 항체가 양성인 루푸스와 다발성 근염이 중 복된 32세 여자 환자를 경험하였기에 문헌고찰과 함께 보고하는 바이다.


College of Medicine, Dankook University, Cheonan, Korea Generalized myalgia and muscle tenderness are relatively common during exacerbations in patients with systemic lupus erythematosus (lupus), and inflammatory myositis involving the proximal muscles occurs in 5∼11% of patients during the course of the disease. However, patients with overlap syndrome of lupus and idiopathic inflammatory myopathy have been not that frequent. We described 2 patients with overlap syndrome of these two diseases. Patient 1 was a 27-year-old female patient concurrently having lupus and dermatomyositis. She manifested the characteristic skin rash for dermatomyositis such as heliotrope rash. Patient 2 was a 32-year-old female patient concurrently having lupus and polymyositis, in whom the disease-specific autoantibodies for lupus or idiopathic inflammatory myopathy such as anti-ds DNA antibody, anti-Sm antibody and anti-Jo-1 antibody were positive.(Korean J Med 65:604-609, 2003)


College of Medicine, Dankook University, Cheonan, Korea Generalized myalgia and muscle tenderness are relatively common during exacerbations in patients with systemic lupus erythematosus (lupus), and inflammatory myositis involving the proximal muscles occurs in 5∼11% of patients during the course of the disease. However, patients with overlap syndrome of lupus and idiopathic inflammatory myopathy have been not that frequent. We described 2 patients with overlap syndrome of these two diseases. Patient 1 was a 27-year-old female patient concurrently having lupus and dermatomyositis. She manifested the characteristic skin rash for dermatomyositis such as heliotrope rash. Patient 2 was a 32-year-old female patient concurrently having lupus and polymyositis, in whom the disease-specific autoantibodies for lupus or idiopathic inflammatory myopathy such as anti-ds DNA antibody, anti-Sm antibody and anti-Jo-1 antibody were positive.(Korean J Med 65:604-609, 2003)